I just gave an invited plenary talk at the joint annual meeting of the Japanese Society of Mathematical Biology and Society of Mathematical Biology in Osaka Japan. I talked about my work on steroid-regulated gene transcription. The slides are here. Previous posts on the topic, including background summaries, can be found here.
I’m currently in Banff, Alberta for a Festschrift for Jack Cowan (webpage here). Jack is one of the founders of theoretical neuroscience and has infused many important ideas into the field. The Wilson-Cowan equations that he and Hugh Wilson developed in the early seventies form a foundation for both modeling neural systems and machine learning. My talk will summarize my work on deriving “generalized Wilson-Cowan equations” that include both neural activity and correlations. The slides can be found here. References and a summary of the work can be found here. All videos of the talks can be found here.
Addendum: 17:44. Some typos in the talk were fixed.
Addendum: 18:25. I just realized I said something silly in my talk. The Legendre transform is an involution because the transform of the transform is the inverse. I said something completely inane instead.
I’m currently at the National Center for Theoretical Sciences, Math Division, on the campus of the National Tsing Hua University, Hsinchu for the 2013 Conference on Mathematical Physiology. The NCTS is perhaps the best run institution I’ve ever visited. They have made my stay extremely comfortable and convenient.
Here are the slides for my talk on Correlations, Fluctuations, and Finite Size Effects in Neural Networks. Here is a list of references that go with the talk
M.A. Buice and C.C. Chow, `Correlations, fluctuations and stability of a finite-size network of coupled oscillators’. Phys. Rev. E 76 031118 (2007) [PDF]
M.A. Buice, J.D. Cowan, and C.C. Chow, ‘Systematic Fluctuation Expansion for Neural Network Activity Equations’, Neural Comp., 22:377-426 (2010) [PDF]
C.C. Chow and M.A. Buice, ‘Path integral methods for stochastic differential equations’, arXiv:1009.5966 (2010).
M.A. Buice and C.C. Chow, `Effective stochastic behavior in dynamical systems with incomplete incomplete information.’ Phys. Rev. E 84:051120 (2011).
MA Buice and CC Chow. Dynamic finite size effects in spiking neural networks. PLoS Comp Bio 9:e1002872 (2013).
MA Buice and CC Chow. Generalized activity equations for spiking neural networks. Front. Comput. Neurosci. 7:162. doi: 10.3389/fncom.2013.00162, arXiv:1310.6934.
Here is the link to relevant posts on the topic.
I’m currently in Mt. Snow, Vermont to give a talk at the Gordon Research Conference on Computer Aided Drug Design. Yes, I know nothing about drug design. I am here because the organizer, Anthony Nicholls, asked me to give a pedagogical talk on Bayesian Inference. My slides are here. I only arrived yesterday but the few talks I’ve seen have been quite interesting. One interesting aspect of this conference is that many of the participants are from industry. The evening sessions are meant to be of more general interest. Last night were two talks about how to make science more reproducible. As I’ve posted before, many published results are simply wrong. The very enterprising Elizabeth Iorns has started something called the Reproducibility Initiative. I am not completely clear about how it works but it is part of another entity she started called Science Exchange, which helps to facilitate collaborations with a fee-for-service model. The Reproducibility Initiative piggy backs on Science Exchange by providing a service (for a fee) to validate any particular result. Papers that pass approval get a stamp of approval. It is expected that pharma would be interested in using this service so they can inexpensively check if possible drug targets actually hold up. Many drugs fail at phase three of clinical trials because they’ve been shown to be ineffective and this may be due to the target being wrong to start with.
On a final note, I flew to Albany and drove here. Unlike in the past when I would have printed out a map, I simply assumed that I could use Google Maps on my smart phone to get here. However, Google Maps doesn’t really know where Mt. Snow is. It tried to take me up a dirt road to the back of the ski resort. Also, just after I turned up the road, the phone signal disappeared so I was blind and had no paper backup. I was suspicious that this was the right way to go so I turned back to the main highway in hopes of finding a signal or a gas station to ask for directions. A few miles down Route 9, I finally did get a signal and also found a sign that led me the way. Google Maps still tried to take me the wrong way. I should have followed what I always tell my daughter – Always have a backup plan.
I just gave a talk on obesity at a diabetes course at the American College of Physicians meeting in San Francisco. My slides are here.