Talk at GRC

I’m currently in Mt. Snow, Vermont to give a talk at the Gordon Research Conference on Computer Aided Drug Design. Yes, I know nothing about drug design. I am here because the organizer, Anthony Nicholls, asked me to give a pedagogical talk on Bayesian Inference. My slides are here. I only arrived yesterday but the few talks I’ve seen have been quite interesting. One interesting aspect of this conference is that many of the participants are from industry. The evening sessions are meant to be of more general interest. Last night were two talks about how to make science more reproducible. As I’ve posted before, many published results are simply wrong. The very enterprising Elizabeth Iorns has started something called the Reproducibility Initiative. I am not completely clear about how it works but it is part of another entity she started called Science Exchange, which helps to facilitate collaborations with a fee-for-service model. The Reproducibility Initiative piggy backs on Science Exchange by providing a service (for a fee) to validate any particular result. Papers that pass approval get a stamp of approval. It is expected that pharma would be interested in using this service so they can inexpensively check if possible drug targets actually hold up. Many drugs fail at phase three of clinical trials because they’ve been shown to be ineffective and this may be due to the target being wrong to start with.

On a final note, I flew to Albany and drove here. Unlike in the past when I would have printed out a map, I simply assumed that I could use Google Maps on my smart phone to get here. However, Google Maps doesn’t really know where Mt. Snow is. It tried to take me up a dirt road to the back of the ski resort. Also, just after I turned up the road, the phone signal disappeared so I was blind and had no paper backup. I was suspicious that this was the right way to go so I turned back to the main highway in hopes of finding a signal or a gas station to ask for directions. A few miles down Route 9, I finally did get a signal and also found a sign that led me the way. Google Maps still tried to take me the wrong way. I should have followed what I always tell my daughter – Always have a backup plan.


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