I visited the Gatsby Computational Neuroscience Unit in London on Friday. I talked about how the dynamics of many observed neural responses to visual stimuli can be explained by varying just two parameters in a “micro-cortical circuit” at the sub-millimetre level. The circuit consists of recurrent excitation, lateral inhibition and fatigue mechanisms like synaptic depression. Recurrently connected pools of neurons inhibit other pools and the competition between pools with fatigue leads to all the varied observed responses we see. I also covered my recent paper on autism where we describe how perturbing the synaptic balance in the micro-cortical circuit can then lead to alterations in performance of simple saccade tasks that seem to match clinical observations. My slides for the talk are here.