Comments on: Eating less won’t make you live longer

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http://forums.blur.co.uk — Thu, 13 Dec 2012 10:38:09 +0000

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By: exfenestracide

exfenestracide — Tue, 04 Sep 2012 09:00:27 +0000

It may be related to the way the diet was carried out.
It has been conjectured, and shown in some animals, that a period of fasting (ex. 8 hours a day intermittent fasting) can prolong life.
Maybe the older study’s diet involved longer periods between meals that could have sparked off that effect.

By: Carson Chow

Carson Chow — Thu, 30 Aug 2012 12:34:34 +0000

I agree that calorie restriction may have some beneficial effects that could help extend lifespan but as you say it is a pretty blunt measure. I just think there will be no noticeable effect in practice because of the many confounders.

By: redzengenoist

redzengenoist — Thu, 30 Aug 2012 01:21:58 +0000

2012: 34 monkeys, P = 0.003.

2009: 76 monkeys, P = 0.03

Not saying that I’m sanguine either way, but since studies of other animals with larger populations tend to align with the 2009 study, and since both 2009 and 2012 studies are pretty much tumorous balls of confounder layered upon confounder, I can’t feel confident that the hypothesis is much impacted (either way) by the two 2009 and 2012 monkey studies.

I wonder, are you also more impressed by the higher-n studies of smaller animals, or the findings of reduced atherosclerosis in large animals like humans, or by the other, higher n studies of measures of variables other than longevity in large mammals? I mean, longevity is a single, nuance-less data point, and almost certainly subject to unplanned, experimental confounding in experiments on such unpredictable, expensive animals.

This reminds me of James’ paper, BTW.